Cart
sales@molnova.com
SirT1 enhancer A03
CAS No. 66171-75-3
SirT1 enhancer A03 ( Alaproclate, (S)-; (-)-Alaproclate; S-(-)-Alaproclate )
Catalog No. M15521 CAS No. 66171-75-3
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSirT1 enhancer A03
-
NoteResearch use only, not for human use.
-
Brief DescriptionSirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
-
DescriptionSirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity
-
SynonymsAlaproclate, (S)-; (-)-Alaproclate; S-(-)-Alaproclate
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number66171-75-3
-
Formula Weight255.74
-
Molecular FormulaC13H18ClNO2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN[C@@H](C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O
-
Chemical Name1-(4-chlorophenyl)-2-methylpropan-2-yl alaninate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574.
molnova catalog
related products
-
SRT 3025
SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein.
-
Sirt2-IN-1
Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
-
SirT1 enhancer A03
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
