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SirT1 enhancer A03

CAS No. 66171-75-3

SirT1 enhancer A03( Alaproclate, (S)- | (-)-Alaproclate | S-(-)-Alaproclate )

Catalog No. M15521 CAS No. 66171-75-3

SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SirT1 enhancer A03
  • Note
    Research use only, not for human use.
  • Brief Description
    SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
  • Description
    SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Alaproclate, (S)- | (-)-Alaproclate | S-(-)-Alaproclate
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66171-75-3
  • Formula Weight
    255.742
  • Molecular Formula
    C13H18ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N[C@@H](C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O
  • Chemical Name
    1-(4-chlorophenyl)-2-methylpropan-2-yl alaninate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574.
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